Novel Coronavirus

[KayTheCurler]

I wonder if, in general, those living in China are less healthy overall and more susceptable to 'germs'.? The people from other places would tend to be those who can afford air travel and possibly more nutritious food.

 

[Luce NDs]

Excess socialism????????? They need space ... thus in Eire ... implosion!

 

[Luce NDs]

Life has its ups and downs! Jumped-up!!!!!!!!!

What can we learn from it to become for cognizant in the land of psyche ... a never before seen item of curiosity!

Not much it appears under unrestricted desires and hope for political pleasures ... extreme Joyce ... Joy's!

At ease stand down from it ... it is just word! Tao time or floater in d'howl ?

 

[Kimmio Laughterlove]

I wonder if, in general, those living in China are less healthy overall and more susceptable to 'germs'.? The people from other places would tend to be those who can afford air travel and possibly more nutritious food.

I think their diet is probably healthier than average North American diets.

 

[Kimmio Laughterlove]

It probably has something to do with more people living together in close quarters.

 

[Mendalla]

Yeah and the great nation of Thailand (sarcasm) has developed the most promising vaccine....

Not a vaccine. They are the ones who are using the antivirals used for HIV.

What? Okay, something is really off...

Why? It's an anti-viral drug. Why not test it to see if works against the corona virus?

 

[Mendalla]

I think their diet is probably healthier than average North American diets.

It probably has something to do with more people living together in close quarters.

These two together are the correct answer. In fact, urban parts of China where they have proper medical care have a life expectancy comparable to or better than North Americans with the Chinese diet being a big part of that. I imagine that as the country brings its rural and remote areas up to the standard you see in cities like Shanghai, they will join the Japanese in having a better life expectancy than us.

Living in close quarters is the answer to why it spreads the way it does. Our penchant for single family dwellings in sprawling suburbs is terrible environmentally speaking but does help with isolating people who are sick.

 

[Luce NDs]

It has not gone viral ... thus anti viral!

 

[Luce NDs]

It has not gone viral ... thus anti viral!

We are wonderfully and individually spread ... great manna!

 

[Waterfall]

Not a vaccine. They are the ones who are using the antivirals used for HIV.



Why? It's an anti-viral drug. Why not test it to see if works against the corona virus?

Yes youre right, I meant "drug cocktail" not vaccine. But still, are patients being used as guinea pigs to try it?

 

[Luce NDs]

Wordy and worldly metaphors ... beyond realities grip! No end tome ...

 

[Waterfall]

Living in close quarters is the answer to why it spreads the way it does. Our penchant for single family dwellings in sprawling suburbs is terrible environmentally speaking but does help with isolating people who are sick.

India and other Asian countries have similar living arrangements to China but the spread is still as of yet limited.

 

[Mendalla]

India and other Asian countries have similar living arrangements to China but the spread is still as of yet limited.

If it actually gets loose in them, I imagine you'll see similar. Right now. countries are being very cautious with this. In China's case, the outbreak was probably well underway before they even realized what it was.

 

[Mendalla]

Yes youre right, I meant "drug cocktail" not vaccine. But still, are patients being used as guinea pigs to try it?

The problem is that animal or laboratory trials aren't reliable. A mouse is not a person, as they say. In this case,the drug is already known to be safe for humans and the side effects will be known and documented, so there is really no reason not to go straight to a clinical trial.

 

[Waterfall]

The problem is that animal or laboratory trials aren't reliable. A mouse is not a person, as they say. In this case,the drug is already known to be safe for humans and the side effects will be known and documented, so there is really no reason not to go straight to a clinical trial.

I believe they had to keep increasing the dosage until they got it right.....how much can a human take before side effects overrides "effectiveness"? Of course would I suppose kidney or liver failure is preferred over death if that is the case. Do we know what "survival" looks like on this drug cocktail?

 

[Waterfall]

If it actually gets loose in them, I imagine you'll see similar. Right now. countries are being very cautious with this. In China's case, the outbreak was probably well underway before they even realized what it was.

Which could be the case for India I suppose.....hard to say.....especially in the country areas.

 

[Waterfall]

Lopinavir/Ritonavir/Oseltimivir(Tamiflu) is the drug cocktail used in high dosages.

 

[Mendalla]

I believe they had to keep increasing the dosage until they got it right.....how much can a human take before side effects overrides "effectiveness"? Of course would I suppose kidney or liver failure is preferred over death if that is the case. Do we know what "survival" looks like on this drug cocktail?

Given that similar cocktails of similar drugs are used are used for other conditions, I imagine we have a pretty good idea. I'm not a medical researcher so I don't know what it looks like. I know that HIV patients on cocktails fare pretty well, much better than they would with AIDS but that's basically a chronic condition. Not sure if an acute illness like 2019 nCoV would compare.

Given how mild 2019 nCoV has been for some people (of the three cases to date in Ontario, only one was hospitalized), I wonder if antivirals will even be needed save for the ones that are hospitalized. Most people manage the flu with fairly simple home measures (drink plenty of fluids, take appropriate meds for symptomatic relief, rest), so I imagine this will be the same.

 

[ChemGal]

Off-label use isn't unusual.
Some of the drugs inhibit reverse transcriptase (an enzyme), so it makes sense for them to be active against multiple RNA viruses.
Typically, DNA is used and an enzyme follows it along to make RNA, and it's RNA (specifically mRNA) that is then used for an enzyme to produce proteins. Viruses don't do this on their own - they use cells to do this work for them.

With RNA viruses aka retroviruses, in our cells, the RNA is converted to DNA and this is done by reverse transcriptase which comes from the virus.

There are differences in enzymes from one species to another in general, so the reverse transcriptases might respond a bit differently to the different drugs, but the active sites would probably be very similar, so the drugs should have a certain level of effectiveness for most retroviruses.

Just noting this isn't true of all of the drugs, but some of them would be based on this.

 

[ChemGal]

I believe they had to keep increasing the dosage until they got it right.....how much can a human take before side effects overrides "effectiveness"? Of course would I suppose kidney or liver failure is preferred over death if that is the case. Do we know what "survival" looks like on this drug cocktail?

For those who are HIV positive, when utilizing meds, life expectancies are comparable to the rest of the population.
I'm not sure how often a cocktail is used now though, I know some just need to take 1 pill, but that might have a few different active ingredients within it.