Even though a defining feature from each variant would be nice as a shortened speaking term. I have never even seen the letters/numbers defined (the nomenclature of virology genetics is not something I'm familiar with, in general genetically the stuff I worked on as for specific proteins so I wasn't covering things like the nuances of how genetic tests are even numbered). With the RNA we're just taking about 4 different letters that change. With the proteins I feel like it's easier to have an idea of what has actually changed.
ie pulling from the CDC some information:
The B.1.1.7 variant carries a mutation in the S protein (N501Y) that affects the conformation of receptor-binding domain. This variant has 13 other B.1.1.7 lineage-defining mutations (
Table), several of which are in the S protein, including a deletion at positions 69 and 70 (del69–70) that evolved spontaneously in other SARS-CoV-2 variants and is hypothesized to increase transmissibility (
2,
7). The deletion at positions 69 and 70 causes S-gene target failure (SGTF) in at least one RT-PCR–based diagnostic assay (i.e., with the ThermoFisher TaqPath COVID-19 assay, the B.1.1.7 variant and other variants with the del69–70 produce a negative result for S-gene target and a positive result for the other two targets); SGTF has served as a proxy in the United Kingdom for identifying B.1.1.7 cases (
1).
So the asparagine (N in amine acid code) in position 501 of the S protein has been replaced with a tyrosine (y in amino acid code). May have a short term name of spike 501 tyrosine or even spike 501 'tie' using the first syllable of the amino acid. I realize this name isn't super short, but I feel like it's a more relatable verbal term than B. 1.1.7
With multiple mutations, what we use as the definition feature is likely to occur in the other variants, but I'm just suggesting these as nicknames, so a unique mutation doesn't have to be selected for a nickname, as long as the next variant uses a different feature for the nickname.
Not sure what the virology genetists would say, but probably better than calling it the UK variant.