As living protagonist I add the following for some determined about spells, spelling and spelunking; agonist and other:
Cooperative activation of gene expression by agonists and antagonists mediated by estrogen receptor heteroligand dimer complexes. - PubMed - NCBI
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. Whereas an agonist causes an action, an antagonist blocks the action of the agonist, and an inverse agonist causes an action opposite to that of the agonist.
Then there's:
a person who believes that nothing is known or can be known of the existence or nature of God or of anything beyond material phenomena; a person who claims neither faith nor disbelief in God.
This may be related to our isolation from forbidden knowledge as taboo ... regarding things that are extensively beyond human restrictions by law ... to protect God knows what in the realm of legalist that states things for their own agendas!
What can be added is the question of what we really respect about the unknown things in our genes ... and yet powers are determined to mess with the unknown ... a philosophical disaster that can cause implosions ...
What some people claim to know all about, even in human communication baffles me ... about what I see they don't know diddly! I am impressed with learning ... as a process ... when a great mass is seized by terror ... even of reading in depth! Superficially this appears as meaning something ...
There I allow it to rest as laid out flat ... but not flattery ... flat Eire ... nope!