There is much we do not know - a bit humbling isn't it?
UCLA epidemiologist
Anne Rimoin is not about to wait around for government support for something she thought could help crack some of the mysteries of the coronavirus and save lives.
Rimoin, an infectious disease expert who developed a healthcare worker monitoring program in Democratic Republic of the Congo, wanted to replicate that model here. Rather than write grant proposals and wait months to hear back, she went to a trusted colleague at UCLA — Dr. Grace Aldrovandi, a virology immunology expert who oversees 200 research labs in 18 countries — and together they started the
UCLA COVID-19 Rapid Response Initiative.
If they can raise more money, they’d like to add 4,000 first responders to the study, along with 4,000 more healthcare workers from community hospitals.
“I’m a big fan of this and it’s going to give us some information we don’t currently have,” said Dr. Clayton Kazan, medical director of the L.A. County Fire Department, which is prepared to have a few thousand employees participate in the research as the UCLA effort ramps up.
Seems to be caused by the 'cytokine storm' that the immune system launches.
The story of Dr. Garrett Emery, the ER physician who took ill in Las Vegas ...
He’s a traveling ER doctor but lives in Las Vegas.
“I had difficulty breathing, a cough … some unusual sensations throughout my body and a burning in my chest. It almost felt like I could feel my lungs being damaged," said Emery, who also had a horrible metallic taste in his mouth.
A doctor prescribed hydroxychloroquine,
the antimalarial drug that’s been in the news as a possible cure with potentially harmful side effects, and Zithromax, an antibiotic.
Emery only got worse.
An oximeter, the finger clip that measures the level of oxygen in the blood, showed that he was in the low 80s.
“It should be in the high 90s,” Emery said.
“My respiratory rate increased, I was breathing very quickly and at that point I realized, ‘I gotta go to the hospital.’"
That was on the morning of April 16. His lab work was not great and a chest X-ray showed moderate lung congestion.
He wanted to go home and nurse himself, but kept getting worse, to the point he feared he might have to be intubated and put on a ventilator.
Doctors tried high-flow oxygen for a day, then took another chest X-ray.
“It was one of the worst X-rays I have seen with this disease. Both my lungs were filled with gunk,” Emery said.
He continued to deteriorate, and his doctors recommended an infusion of convalescent plasma.
Marissa Li, a California-based pathologist with Vitalant, a nonprofit blood donation company that’s
accepting and distributing plasma donations, located some plasma that matched Emery’s blood type at Marian Regional Medical Center in Santa Maria.
On April 19 the infusion began around midnight.
“So the next day was the 20th and I was still bad, but in the afternoon things started to improve and I was requiring less oxygen,” Emery said.
“On the morning of the 21st, 36 hours after the infusion, I felt 30% to 40% better."
"I had no fever for the first day in two weeks. … I got my taste back and was able to get the oxygen turned all the way off.”
When someone recovers from COVID-19, it’s not clear why they improved, or whether they would have gotten better without medication.
Emery said he strongly believes the serum did the trick for him, and a phone conversation with Dr. Yu made him all the more certain.
Yu studied Emery’s lab work in collaboration with Emery’s doctors in Nevada.
Yu said Emery was in the midst of a cytokine storm, an often fatal condition in which the body attacks its own cells.
“As a lung specialist and critical-care specialist, I’ve never seen a turnaround like this,” Yu said.
“I’ve seen many cytokine storms, but I’ve never seen one progress to this stage and then make a U-turn.”
Emery went home a few days after receiving the infusion and planned to return to work the following Friday.
A doctor with COVID-19 thought, "My God, I'm going to die." He says an experimental treatment did the trick.
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